Calcineurin/NFATc signaling is required for neuregulin regulated Schwann cell differentiation
β Scribed by S.-C. Kao; G.R. Crabtree; I.A. Graef
- Book ID
- 116551870
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 57 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0736-5748
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Schwann cell proliferation is stimulated by contact with neurons or exposure to growth factor ligands for tyrosine kinase receptors, effects of which are potentiated by cAMP. Here we show that treatment of rat Schwann cells with recombinant human glial growth factor 2 (rhGGF2), but not with other mi
## Abstract Neuregulinβ1 (NRGβ1) proteins promote Schwann cell survival, differentiation and proliferation during development. High levels of an NRGβlike activity are also present in some human peripheral nerve sheath tumors, suggesting that NRGβ1 isoforms may be involved in the development of thes