Chronic renal dysfunction is a frequent and severe complication in solid-organ transplant recipients. Calcineurin inhibitors (CNIs) are the main pathogenic factors of renal dysfunction. Switching from CNIs to nonnephrotoxic drugs, such as mammalian target of rapamycin inhibitors (everolimus and siro
✦ LIBER ✦
Calcineurin inhibitor withdrawal and conversion to mycophenolate mofetil and steroids in cardiac transplant recipients with chronic renal failure: a word of caution
✍ Scribed by Jan Groetzner; Ingo Kaczmarek; Johannes Schirmer; Peter Überfuhr; Helmut Gulbins; Sabine Daebritz; Bruno Meiser; Bruno Reichart
- Book ID
- 110889972
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 131 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0902-0063
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Renal impairment is common in patients after liver transplantation and is attributable in large part to the use of calcineurin inhibitor (CNI)-based immunosuppression. We sought to determine whether conversion to sirolimus-based immunosuppression was associated with improved renal function. In a sin