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Calcein Permeability of Liposomes Mediated by Type A Botulinum Neurotoxin and Its Light and Heavy Chains

โœ Scribed by Fen-Ni Fu; Bal Ram Singh


Book ID
110397616
Publisher
Springer
Year
1999
Tongue
English
Weight
879 KB
Volume
18
Category
Article
ISSN
1573-4943

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โœ Bal Ram Singh; B. R. DasGupta ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Springer ๐ŸŒ English โš– 537 KB

The secondary and tertiary structural features of botulinum neurotoxin (NT) serotype A, a dichain protein (Mr 145,000), and its two subunits, the heavy (H) and light (L) chains (Mr 97,000 and 53,000, respectively) were examined using circular dichroism and fluorescence spectorscopy. Nearly 70% of th