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cagA-positiveHelicobacter pylori and risk for developing gastric carcinoma in Brazil

✍ Scribed by Dulciene M. M. Queiroz; Edilberto N. Mendes; Gifone A. Rocha; Andreia M. R. Oliveira; Celso A. Oliveira; Paula P. Magalhães; Sílvia B. Moura; Mônica M. D. A. Cabral; Ana M. M. F. Nogueira

Book ID
101232839
Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
66 KB
Volume
78
Category
Article
ISSN
0020-7136

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✦ Synopsis

To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.

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✍ Domenico Palli; Giovanna Masala; Giuseppe Del Giudice; Mario Plebani; Daniela Ba 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 246 KB 👁 1 views

## Abstract __Helicobacter pylori__ (__H. pylori__), atrophic gastritis, dietary and life‐style factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case–control study nested in the European Prospective Investigation into Cancer and Nutrition carried o