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CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

โœ Scribed by Lee, J.- M.; Ramos, E. M.; Lee, J.- H.; Gillis, T.; Mysore, J. S.; Hayden, M. R.; Warby, S. C.; Morrison, P.; Nance, M.; Ross, C. A.; Margolis, R. L.; Squitieri, F.; Orobello, S.; Di Donato, S.; Gomez-Tortosa, E.; Ayuso, C.; Suchowersky, O.; Trent, R. J. A.; McCusker, E.; Novelletto, A.; Frontali, M.; Jones, R.; Ashizawa, T.; Frank, S.; Saint-Hilaire, M. H.; Hersch, S. M.; Rosas, H. D.; Lucente, D.; Harrison, M. B.; Zanko, A.; Abramson, R. K.; Marder, K.; Sequeiros, J.; Paulsen, J. S.; Landwehrmeyer, G. B.; Myers, R. H.; MacDonald, M. E.; Gusella, J. F.

Book ID
118127514
Publisher
Lippincott Williams and Wilkins
Year
2012
Tongue
English
Weight
448 KB
Volume
78
Category
Article
ISSN
0028-3878

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## Abstract The ATP/ADP ratio reflects mitochondrial function and has been reported to be influenced by the size of the Huntington disease gene (__HD__) repeat. Impaired mitochondrial function has long been implicated in the pathogenesis of Parkinson's disease (PD), and therefore, we evaluated the