Cadherin Expression in Uveal Melanoma
โ Scribed by Gerasimos Anastassiou; Frank Tschentscher; Michael Zeschnigk; Norbert Bornfeld
- Book ID
- 115605863
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 70 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0014-4835
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๐ SIMILAR VOLUMES
## Abstract Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Disease metastasis occurs in half of the patients and is uniformly fatal despite systemic therapy. Inducible nitric oxide synthase (iNOS) is associated with disease progression in various malignancies including
An immunocytochemical study has been undertaken of cadherin expression in 11 benign melanocytic uaevi and 14 malignant melanomas. Anti-pan-cadherin rabbit antibodies, which recognize multiple cadherin subtypes, demonstrated cadherin expression of moderate or strong intensity in 8 of 11 naevi. Expres