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Cadherin expression in glandular tumors of the cervix : Aberrant P-cadherin expression as a possible marker of malignancy

✍ Scribed by Aaron C. Han; Mitchell I. Edelson; Alejandro Peralta Soler; Karen A. Knudsen; Beatriz Lifschitz-Mercer; Bernard Czernobilsky; Norman G. Rosenblum; Hernando Salazar

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 642 KB
Volume: 89
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(20001115)89:10<2053::aid-cncr4>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

The cadherins are homotypic adhesion proteins that are important in cell sorting during organogenesis. Classic cadherins include several different types that show tissue specific expression. Specific tissue expression of cadherins often is preserved in neoplastic transformation, and cadherin phenotype can be used to differentiate morphologically similar but histogenetically distinct tumors.

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