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Cadherin-11 is highly expressed in rhabdomyosarcomas and during differentiation of myoblastsin vitro

✍ Scribed by Markus, Marietta A.; Reichmuth, Claudia; Atkinson, Michael J.; Reich, Ulrike; Hoffmann, Ines; Balling, Rudi; Anderer, Ursula; H�fler, Heinz

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
414 KB
Volume
187
Category
Article
ISSN
0022-3417

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✦ Synopsis

Rhabdomyosarcomas bear a morphological and genetic resemblance to developing skeletal muscle. Apart from myogenic marker genes (bHLH factors, myosin, actin), cell adhesion molecules such as N-cadherin and N-CAM have been reported to be expressed both in rhabdomyosarcomas and during myogenesis. The present study demonstrates the expression of another cadherin, cadherin-11, in rhabdomyosarcomas and during differentiation of myoblasts in vitro: cadherin-11, a predominantly mesenchymal cell adhesion molecule, is highly expressed in embryonal rhabdomyosarcomas and alveolar rhabdomyosarcomas, which do not bear the Pax-3-FKHR fusion previously described. Cadherin-11 is down-regulated in normal skeletal muscle and after myotube formation in vitro. The results of this study suggest that cadherin-11 might be involved in myogenesis and that rhabdomyosarcomas may re-express or fail to down-regulate cadherin-11. Since alveolar rhabdomyosarcomas bearing the t(2;13) translocation do not express cadherin-11, it is postulated that Pax-3 and cadherin-11 might be linked and involved in the same myogenic pathway.

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