Synthesis of 2-Oxacortexone and its Effe
โ
Aryeh A. Frimer; Gladis Aljadeff; Sara Rubinstein; Haim Breitart
๐
Article
๐
1997
๐
John Wiley and Sons
๐
English
โ 519 KB
Low temperature base catalyzed autoxidation (BCA) of the A-ring of 2 1 -acetoxypregn-5-ene-3,2O-dione 20-ethylene ketal (7) resulted in the saponification of the ester with the concomitant formation of 2,2 1 -dihydroxypregna-1,4-diene-3,2O-dione 20-ethylene ketal(8). Continued BCA at ambient tempera