Ca2+ sources for the exocytotic release of glutamate from astrocytes
✍ Scribed by Vladimir Parpura; Vladimir Grubišić; Alexei Verkhratsky
- Book ID
- 113486423
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 499 KB
- Volume
- 1813
- Category
- Article
- ISSN
- 0167-4889
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## Abstract Vesicular glutamate transporters (VGLUTs) are responsible for vesicular glutamate storage and exocytotic glutamate release in neurons and astrocytes. Here, we selectively and efficiently overexpressed individual VGLUT proteins (VGLUT1, 2, or 3) in solitary astrocytes and studied their e
## Abstract Astrocytes can modulate synaptic transmission by releasing glutamate in a Ca^2+^‐dependent manner. Although the internal Ca^2+^ stores have been implicated as the predominant source of Ca^2+^ necessary for this glutamate release, the contribution of different classes of these stores is