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Ca2+-overload inhibits the cardiac SR Ca2+–calmodulin protein kinase activity

✍ Scribed by Thomas Netticadan; Rana M Temsah; Ken-ichi Kawabata; Naranjan S Dhalla


Book ID
117051777
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
153 KB
Volume
293
Category
Article
ISSN
0006-291X

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DEAE-cellulose column chromatography of Neurospora crassa soluble mycelial extracts leads to the resolution of three major protein kinase activity peaks designated PKI, PKII, and PKIII. PKII activity is stimulated by Ca2+ and Neurospora or brain calmodulin. Maximal stimulation was observed at 2 micr