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Ca2+ is mobilized by hydroxyl radical but not by superoxide in RTH-149 cells: The oxidative switching-on of Ca2+ signaling

โœ Scribed by Bruno Burlando; Aldo Viarengo


Book ID
113525525
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
306 KB
Volume
38
Category
Article
ISSN
0143-4160

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The mechanism of the induction of apoptosis by arsenic trioxide (As 2 O 3 ), which was demonstrated recently to be an effective inducer of apoptosis in patients with leukemia, was examined in detail in human leukemia U937 cells. Upon treatment of U937 cells with 50 M of As 2 O 3 , complete inactivat