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Ca2+-Induced Conformational Changes of Na+-Ca2+ Exchanger Dimers: Role of Ca2+ Binding Domains

✍ Scribed by Ottolia, Michela; Ribalet, Bernard; Scott, John; Philipson, Kenneth D.

Book ID
123072980
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
46 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Abstract We examined inhibitory effects of external multivalent cations Ni^2+^, Co^2+^, Cd^2+^, La^3+^, Mg^2+^, and Mn^2+^ on reverse‐mode exchange of the K^+^‐dependent Na^+^/Ca^2+^ exchanger NCKX2 and the K^+^‐independent exchanger NCX1 expressed in CCL‐39 cells by measuring the rate of Ca^2+^