Ca2+-dependent K+channel activity in rat glioma cells induced by bradykinin stimulation and by inositol 1,4,5-trisphosphate injection

Enhanced activity of Ca2+-activated K+ c

Enhanced activity of Ca2+-activated K+ channels by 1-[2-hydroxy-3-propyl-4-[(1H-tetrazol-5-yl)butoxyl]phenyl] ethanone (LY-171883) in neuroendocrine and neuroblastoma cell lines

✍ Ping-Chia Li; Jin-Tung Liang; Hung-Tu Huang; Pei-Hsuan Lin; Sheng-Nan Wu 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB

## Abstract The effects of LY‐171883, an orally active leukotriene antagonist, on membrane currents were examined in pituitary GH~3~ and in neuroblastoma IMR‐32 cells. In GH~3~ cells, LY‐171883 (1–300 μM) reversibly increased the amplitude of Ca^2+^‐activated K^+^ current in a concentration‐depende