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Ca2+ and Zn2+ binding properties of peptide substrates of vertebrate collagenase, MMP-1

โœ Scribed by Nataraj N Vettakkorumakankav; Vettai S Ananthanarayanan


Book ID
114149975
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
423 KB
Volume
1432
Category
Article
ISSN
0167-4838

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โœ Christopher D. Syme; John H. Viles ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 618 KB

Elevated levels of zinc 2+ and copper 2+ are found chelated to the amyloid-beta-peptide (Ah) in isolated senile plaque cores of Alzheimer's disease (AD) patients. However, the precise residues involved in Zn 2+ ligation are yet to be established. We have used 1 H NMR and CD to probe the binding of Z