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CA 494—a new tumor marker for the diagnosis of pancreatic cancer

✍ Scribed by Helmut Friess; Markus Büchler; Bernhard Auerbach; Alexander Weber; Peter Malfertheiner; Kai Hammer; Norbert Madry; Sabine Greiner; Klaus Bosslet; Hans G. Beger

Publisher
John Wiley and Sons
Year
1993
Tongue
French
Weight
569 KB
Volume
53
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

In 59 patients with ductal pancreatic cancer the monoclonal antibody (MAb) BW 494, which detects the CA 494 glycoprotein antigen, was analyzed in comparison with the reference tumor markers CA 19‐9 and CEA. Eighty‐one patients with non‐pancreatic malignancies of the gastraintestinal (GI) tract, 95 with chronic pancreatitis, 124 with benign non‐pancreatic GI diseases, 30 with diabetes mellitus (type I or type II) and I14 healthy blood donors served as controls. The sensitivity of pancreatic cancer was 90%, 44% and 90% for CA 19‐9, CEA and CA 494, respectively. In chronic pancreatitis, as the most important control population for pancreatic cancer, the specificity was 85%, 72% and 94% for CA 19‐9, CEA and CA 494, respectively.

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