## Abstract ## BACKGROUND Folate is an important B vitamin that is transported into cells by way of folateβbinding proteins and transporters. Folateβbinding proteinβ2 nullizygous (Folbp2^β/β^) mice develop normally; however, we have found them to be more susceptible to the teratogenic effects of a
β¦ LIBER β¦
C5aR protects against folate-deficiency induced neural tube defects in mice
β Scribed by K.J. Costantini; L.G.J. Coulthard; M. Lor; T.M. Woodruff; L.K. Callaway; R.H. Finnell; S.M. Taylor
- Book ID
- 116757705
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 70 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0161-5890
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## BACKGROUND: The etiology of neural tube defects (NTDs) is multifactorial, with environmental and genetic determinants. Folate supplementation prevents the majority of NTDs, and a polymorphism in methylenetetrahydrofolate reductase (MTHFR) has become recognized as a genetic risk factor. The mech