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C4Agene deletion and HLA associations in black Americans with systemic lupus erythematosus

✍ Scribed by Mary L. Olsen; Rose Goldstein; Frank C. Arnett; Madeleine Duvic; Marilyn Pollack; John D. Reveille


Publisher
Springer-Verlag
Year
1989
Tongue
English
Weight
858 KB
Volume
30
Category
Article
ISSN
0093-7711

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In a study of 59 black American patients with systemic lupus erythematosus (SLE), we found that partial C4A deficiency occurred twice as frequently as in 59 control subjects (32.3% versus 15.3%; P = 0.02). Complete C4A deficiency, however, occurred in only 1 patient and in no controls. Partial C4A

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## Abstract ## Objective To examine the extent of organ damage among recently diagnosed patients with systemic lupus erythematosus (SLE), and to assess the association between sociodemographic variables and total damage and organ‐specific damage scores. ## Methods We evaluated damage in 132 pati