C3a receptor antagonist attenuates brain injury after intracerebral hemorrhage
β Scribed by Rynkowski, Michal A; Kim, Grace H; Garrett, Matthew C; Zacharia, Brad E; Otten, Marc L; Sosunov, Sergei A; Komotar, Ricardo J; Hassid, Benjamin G; Ducruet, Andrew F; Lambris, John D
- Book ID
- 109871125
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 317 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0271-678X
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π SIMILAR VOLUMES
## Abstract Many studies have indicated leukocytes are a major contributor to brain injuries caused by intracerebral hemorrhage (ICH). Leukocyteβexpressed CD18 is important for neutrophilβendothelial interactions in the vasculature, and CD18 deficiency protects against ischemiaβreperfusion injury.
Endothelins (ETs) are suggested to be involved in pathological or pathophysiological responses on brain injuries. In the present study, an involvement of ETs on activation of astrocytes in vivo was examined by using selective endothelin receptor antagonists. A stab wound injury on rat cerebral corte