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C3 and CD46 deficiencies: Similar B cell phenotype and defect in Th1/Th2/Tr1 polarization

✍ Scribed by A. Ghannam; S. Weller; J.-L. Fauquert; C. Thomas; C. Contin-Bordes; C. Kemper; C. Drouet

Book ID
113805575
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
74 KB
Volume
48
Category
Article
ISSN
0161-5890

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✍ Karine Serre; Elodie Mohr; Cécile Bénézech; Roger Bird; Mahmood Khan; Jorge H. C 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 878 KB

## Abstract NF‐κB1‐dependent signaling directs the development of CD4^+^ Th2 cells during allergic airway inflammation and protective responses to helminth infection. Here, we show that IL‐4 and IL‐13 production is NF‐κB1‐dependent in mouse OVA‐specific CD4^+^ (OTII) T cells responding to alum‐prec