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C10 N-Acyl modified FK-506: A possible hybrid analogue of the transition state of peptidyl-prolyl cis-trans isomerization.

✍ Scribed by D.K. Donald; M.E. Cooper; M. Furber; E. Wells; R. Hutchinson; F.M. Black


Book ID
104216107
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
223 KB
Volume
32
Category
Article
ISSN
0040-4039

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✦ Synopsis


Three C 10 N-Acyl derivatives of FK-506 have been prepared. The reduced receptor binding of these analogues is not consistent with a direct overlap of FK-506 and a peptide substrate.