C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase Ce/Nrf2 pathway

C-terminal mechano-growth factor induces

C-terminal mechano-growth factor induces heme oxygenase-1-mediated neuroprotection of SH-SY5Y cells via the protein kinase Cϵ/Nrf2 pathway

✍ Arnulfo Quesada; Julie Ogi; James Schultz; Adrian Handforth 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 465 KB

Recently, a variant of insulin-like growth factor-1, mechano-growth factor (MGF), has been discovered whose 24-amino-acid carboxy end is protective in models of stroke, nerve injury, and amyotrophic lateral sclerosis, suggesting broad-spectrum neuroprotective properties. Moreover, we recently demons