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C-Src Activation by ErbB2 Leads to Attachment-Independent Growth of Human Breast Epithelial Cells

✍ Scribed by Lewis G. Sheffield

Book ID: 115582597
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 104 KB
Volume: 250
Category: Article
ISSN: 0006-291X
DOI: 10.1006/bbrc.1998.9214

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## Abstract MCF‐ 10A is a spontaneously immortalized, non‐transformed human mammary epithelial cell line. We have recently obtained MCF‐ 10A clones (MCF‐ 1OA HE cells) that are transformed following over‐expression of both a human point‐mutated c‐Ha‐__ras__ and the c‐__erb__B‐2 proto‐oncogenes. Two