C-peptide improves neuropathy in type 1 diabetic BB/Wor-rats
✍ Scribed by Weixian Zhang; Hideki Kamiya; Karin Ekberg; John Wahren; Anders A. F. Sima
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 149 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1520-7552
- DOI
- 10.1002/dmrr.672
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## Abstract ## Aims/Hypothesis C‐peptide reduces renal damage in diabetic patients and experimental animal models. __In vitro__ studies suggest that the renal effects of C‐peptide may, in part, be explained by stimulation of Na^+^/K^+^‐ATPase activity. However, the responses of Na^+^/K^+^‐ATPase e
## Abstract ## Background Type 1 diabetes results from a T‐cell mediated autoimmune destruction of insulin‐producing pancreatic beta‐cells. The 60‐kDa heat‐shock protein (hsp60) is one of the known target self‐antigens. An immunogenic peptide from hsp60, p277, arrested beta‐cell destruction and ma