๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

C. parvum treatment of transplanted rat tumours of spontaneous origin

โœ Scribed by N. Willmott; M. V. Pimm; R. W. Baldwin

Book ID
102863500
Publisher
John Wiley and Sons
Year
1979
Tongue
French
Weight
531 KB
Volume
24
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Abstract

C. parvum (Wellcome CN6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. With five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. Equivalent dry weights of Glaxo, Pasteur or Connaught BCGs were relatively ineffective. Intralesional injection of C. parvum into three established tumours (two mammary carcinomas and one fibrosarcoma) retarded development of only one, the mammary carcinoma Sp4. With three mammary carcinomas and one fibrosarcoma, active specific immune stimulation with vaccines of viable or irradiated cells admixed with C. parvum was again consistently effective only with carcinoma Sp4, and this tumour was also susceptible to intradermal but not intravenous treatment with C. parvum alone.

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