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c-myc Repression of Promoter Activity through Core Promoter Elements

✍ Scribed by J.M. Lucas; N.M. Wilkie; J.C. Lang

Book ID
115573366
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
350 KB
Volume
194
Category
Article
ISSN
0006-291X

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In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. This suppression has severe consequences for the recognition of these tumor cells by the immune system of the organism. We show here that transcription of the HLA-B locus, which is mainly affected by c-Myc, is