c-myc oncoprotein levels in bladder cancer

✍ Scribed by Masters, J.R.W. ;Vesey, S.G. ;Munn, C.F. ;Evan, G.I. ;Watson, J.V.

• Book ID: 104686024
• Publisher: Springer
• Year: 1988
• Tongue: English
• Weight: 351 KB
• Volume: 16
• Category: Article
• ISSN: 0300-5623
• DOI: 10.1007/bf00256039

✦ Synopsis

The protein coded by the oncogene c-myc, p62c-myc, was measured using monoclonal antibodies and flow cytometry in nuclei derived from paraffin-wax sections of transitional cell carcinomas of the human bladder. Superficial disease (stages pTa and pT1) which did not recur within 5 years of diagnosis had significantly higher oncoprotein levels than those which did recur or were muscle-invasive (stage pT2 or greater) at presentation (P less than 0.01). These preliminary findings indicate that oncoprotein levels might have prognostic significance for bladder cancer.