C-myc oncogene expression: A marker for females at risk of breast carcinoma

✍ Scribed by Dermot J. Hehir; Gerald McGreal; William O. Kirwan; William Kealy; Dr. Michael P. Brady

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 332 KB
• Volume: 54
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930540402

✦ Synopsis

In an attempt to identify patients at risk of breast cancer, 9E 10 c-myc monoclonal antibody was used to detect the oncogene products in 64 breast tissue biopsies. There were 44 specimens of benign breast disorders: 21 from patients who developed subsequent breast cancer, and 23 from patients who did not. The remainder were malignant tumor biopsies from those who developed breast cancer. C-myc over-expression was identified in 12 (60%) of the breast carcinomas; it was also noted in 13 (62%) of the benign biopsies from patients who developed subsequent breast carcinoma. Expression was observed in only 3 (13%) controls-patients who did not develop cancer. A prospective study is now warranted to determine the clinical usefulness of our findings. 0 I993 WiIey-Liss, Inc.