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c-Met Is a Potentially New Therapeutic Target for Treatment of Human Melanoma

✍ Scribed by Puri, N.; Ahmed, S.; Janamanchi, V.; Tretiakova, M.; Zumba, O.; Krausz, T.; Jagadeeswaran, R.; Salgia, R.

Book ID
115462101
Publisher
American Association for Cancer Research
Year
2007
Tongue
English
Weight
561 KB
Volume
13
Category
Article
ISSN
1078-0432

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c-Met, a high-affinity receptor for hepatocyte growth factor (HGF), plays a critical role in cancer growth, invasion, and metastasis. Hepatocellular carcinoma (HCC) patients with an active HGF/c-Met signaling pathway have a significantly worse prognosis. Although targeting the HGF/c-Met pathway has