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c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases

✍ Scribed by Zhao-Shi Zeng; Martin R. Weiser; Eleanor Kuntz; Chin-Tung Chen; Sajid A. Khan; Ann Forslund; Garrett M. Nash; Mark Gimbel; Yuka Yamaguchi; Alfred T. Culliford IV; Matthew D’Alessio; Francis Barany; Philip B. Paty

Book ID
116334719
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
726 KB
Volume
265
Category
Article
ISSN
0304-3835

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## Abstract MDM2 is a crucial negative regulator of the TP53 tumor suppressor and almost 10% of human tumors exhibit __MDM2__ amplification. Although TP53 pathway perturbation has been extensively examined in colorectal cancer (CRC), only one previous report has evaluated __MDM2__ amplification in