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C-Kit receptor (CD117) expression on myeloblasts and white blood cell counts in acute myeloid leukemia

✍ Scribed by Wo?niak, Jolanta ;Kope?-Szl?zak, Joanna

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 294 KB
Volume: 58B
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.b.10068

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GM-CSF is a major regulator of myelopoiesis. Recombinant human GM-CSF (250 micrograms/m2 per day i.v.) was used prior to chemotherapy ("3 + 7" scheme) to recruit leukemic blasts in vivo (de novo AML patients, n = 20) into the chemotherapy sensitive phases of the cell cycle. The stimulatory effect of