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c-fos proto-oncogene expression in human NK/LGL cells: Expression is not constitutive and is associated with functional activation

✍ Scribed by Francesco Colotta; Nadia Polentarutti; Anna Pirelli; Maria Dibello; Paola Allavena; Alberto Mantovani

Book ID: 102867397
Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 531 KB
Volume: 42
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910420513

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✦ Synopsis

Unlike mature myeloid and monocytic cells and cell lines committed to terminal myelomonocytic differentiation, highly purified preparations of human natural killer cells/large granular lymphocytes (NWLGL) did not spontaneously express the c-fos proto-oncogene. Transient expression of c-fos in NWLGL was associated with functional activation with IL-2, IFN-7, LPS and PMA, which increased their cytotoxic activity, lymphokine secretion and in vitro chemotaxis. These results, together with the finding that T-cell receptor genes are in germ-line configuration in the vast majority of peripheral blood NWLGL, are compatible with the hypothesis that these cells represent a separate hematopoietic lineage.

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