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c-erbB2 expression predicts tamoxifen efficacy in breast cancer patients

โœ Scribed by Sabino De Placido; Chiara Carlomagno; Michelino De Laurentiis; AngeloRaffaele Bianco


Book ID
110232660
Publisher
Springer US
Year
1998
Tongue
English
Weight
639 KB
Volume
52
Category
Article
ISSN
0167-6806

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## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer