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C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

✍ Scribed by Clark, Scott G.; Stern, Michael J.; Horvritz, H. Robert


Book ID
109780075
Publisher
Nature Publishing Group
Year
1992
Tongue
English
Weight
895 KB
Volume
356
Category
Article
ISSN
0028-0836

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## Abstract We have determined the thermodynamic stability and peptide binding affinity of the carboxy‐terminal Src homology 3 (SH3) domain from the __Caenorhabditis elegans__ signal‐transduction protein Sem‐5. Despite its small size (62 residues) and lack of disulfide bonds, this domain is highly