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C-capping and helix stability: the pro C-capping motif

✍ Scribed by Jesús Prieto; Luis Serrano

Book ID
115628170
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
392 KB
Volume
274
Category
Article
ISSN
0022-2836

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A helical capping motif in ShK toxin and
A helical capping motif in ShK toxin and its role in helix stabilization
✍ Mark D. Lanigan; Jane E. Tudor; Michael W. Pennington; Raymond S. Norton 📂 Article 📅 2001 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 227 KB

ShK toxin, a 35-residue polypeptide cross-linked by three disulfides, is a potent blocker of voltage-gated potassium channels and is of interest as a lead in the development of new immunosuppressant agents. ShK toxin contains two short stretches of alpha-helix, the first of which is preceded by a pu