C-14 labelling of NVP VID400—a specific vitamin D3-hydroxylase inhibitor

Synthesis of isotopically labelled [14C]

Synthesis of isotopically labelled [14C]ZT-1 (Debio-9902), [d3]ZT-1 and (−)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors

✍ Loïc Leman; Sean L Kitson; Rodney T Brown; Jana Cairns; William Watters; Austin 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 French ⚖ 515 KB

A method has been developed for the synthesis of two isotopically labelled forms of a pro‐drug of the acetylcholinesterase inhibitor (−)‐huperzine A. These labelled compounds,[^14^C]ZT‐1 (Debio‐9902) and [d~3~]ZT‐1, were used in clinical studies to evaluate a potential treatment for Alzheimer's dise