𝔖 Bobbio Scriptorium
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C-10 substituted 19-norsteroids IX. Introduction of 10β substituents

✍ Scribed by Jack Fishman; Henry Guzik

Book ID
104215535
Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
185 KB
Volume
7
Category
Article
ISSN
0040-4039

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✦ Synopsis

The introduction of substituents at C-10 in 19-not-steroids proceeds preferentially* or even exclusively3 from the a-side. The 91x, 1Oa compounds so obtained represent a class of interesting "unnatural" steroids difficult to obtain by other routes; 10s substituted steroids are more readily available by modification of an existing C-19 4 methyl group of natural products via the Barton reaction or lead tetracetate oxidation, 5 11. R. Gardi and C. Pedralli Gas. Chim. Ital., 91: 1420 (1Wl). 12

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