𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Bystander effects: A concept in need of clarification

✍ Scribed by Bozidar Djordjevic

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
108 KB
Volume
22
Category
Article
ISSN
0265-9247

No coin nor oath required. For personal study only.

✦ Synopsis

An increasing body of evidence indicates that the response to genotoxic agents such as radiation or drugs is a group phenomenon, rather than the summed response of individual independent cells to injury. Thus, a complex contagion-like response may spread beyond the initial impact of an agent to enlarge its effect. This indirect effect, termed ``Bystander Effect,'' is multifaceted and may play a significant role in the therapy of tumors and in carcinogenesis. A better understanding of this phenomenon is needed in order to modulate treatment protocols to therapeutic advantage and to provide more rational guidelines for the evaluation of environmental hazards.

πŸ“œ SIMILAR VOLUMES

Natural selection: A concept in need of
Natural selection: A concept in need of some evolution?
✍ Charles H. Smith πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 130 KB

## Abstract In some respects natural selection is a quite simple theory, arrived at through the logical integration of three propositions (the presence of variation within natural populations, an absolutely limited resources base, and procreation capacities exceeding mere replacement numbers) whose

Cyclooxygenase-2 as a signaling molecule
Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect
✍ Tom K. Hei πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 119 KB

## Abstract Radiation‐induced bystander effect represents a paradigm shift in our understanding of the radiobiological effects of ionizing radiation in that extranuclear and extracellular effects may also contribute to the final biological consequences of exposure to low doses of radiation. Evidenc

Need for the clarification of data in a
Need for the clarification of data in a recent meta-analysis about cytokine gene polymorphisms and acute liver graft rejection
✍ Fei Liu; Yonggang Wei; Bo Li; Lvnan Yan πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 46 KB

A Meta-Analysis,'' 1 which was published in Liver Transplantation in 2005. The results suggest that the interleukin-10 (IL-10) polymorphism at position Γ€1082 has been identified as a genetic risk factor for acute liver graft rejection: liver transplant recipients carrying the IL-10-1082 A allele dis