Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse
Butyrylcholinesterase K variant and Alzheimer’s disease
✍ Scribed by P. K. Panegyres; Cyril D. S. Mamotte; Sam D. Vasikaran; Steve Wilton; Vicki Fabian; Byron A. Kakulas
- Publisher
- Springer
- Year
- 1999
- Tongue
- English
- Weight
- 22 KB
- Volume
- 246
- Category
- Article
- ISSN
- 0340-5354
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Increased butyrylcholinesterase (BChE) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of Alzheimer disease (AD). Because the catalytic activity of BChE-K variant is reduced by one-thir
## Abstract ## Objective Individuals with a clinical diagnosis of Alzheimer's disease (AD) may have prominent features of executive dysfunction and language impairment as well as behavioral abnormalities early in the disease (‘high frontality’). When this occurs differentiation from frontotemporal