Butyric monosaccharide ester-induced cell differentiation and anti-tumor activity in mice. Importance of their prolonged biological effect for clinical applications in cancer therapy
✍ Scribed by Philippe Pouillart; Italina Cerutti; Gino Ronco; Pierre Villa; Charles Chany
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 831 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
✦ Synopsis
The interest of butyric salts is based on their capacity to promote differentiation of malignant cells and inhibition of tumor development. The phenotypic modifications are rapidly reversible and require the continuous presence of butyric salts in the target area, which raises problems for therapeutic applications. We show here that the covalent binding of nbutyric acid on natural polyhydroxylated compounds such as monosaccharides, especially 3or 6-0-butanoyl-I ,2-O-iropropylidene-a-D-glucofuranose, retains the majority of the biological properties of n-butyric acid. The delayed degradation of these covalent compounds is associated with an improved maintenance of cell differentiation and anti-tumor protection in mice. These butyric complexes thus seem potentially useful for therapeutic applications.