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Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells

✍ Scribed by Yu Zhang; Liang Zhou; Yong Li Bao; Yin Wu; Chun Lei Yu; Yan Xin Huang; Ying Sun; Li Hua Zheng; Yu Xin Li

Book ID
113518172
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
751 KB
Volume
185
Category
Article
ISSN
0009-2797

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## Abstract Sodium 4‐phenylbutyrate (PB) has been used in the therapy of urea cycle defects for many years. Recently, it has been shown to cause cellular differentiation, growth arrest, and apoptosis in certain malignancies. We have analyzed the effects of PB on human lung carcinoma cells. PB has d