Buspirone attenuates learned helplessness behavior in rats

✍ Scribed by Robert C. Drugan; Jacqueline N. Crawley; Steven M. Paul; Phil Skolnick

• Book ID: 102140927
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 317 KB
• Volume: 10
• Category: Article
• ISSN: 0272-4391
• DOI: 10.1002/ddr.430100204

✦ Synopsis

Rats pretreated with either chlordiazepoxide (5 mglkg) or buspirone (5 mg/kg) did not develop the shuttlebox escape deficit typically observed 24 hours after a session of inescapable tailshock. In contrast, the buspirone analog gepirone (MJ 13805) (2 or 5 mgl kg) did not block this shock-induced learning deficit. These results demonstrate that the nonbenzodiazepine anxiolytic buspirone, like chlordiazepoxide, attenuates the learned helplessness syndrome.