Bupropion and alcohol fatal intoxication: Case report

✍ Scribed by Vera Ramcharitar; Barry S. Levine; Bruce A. Goldberger; Yale H. Caplan

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 417 KB
• Volume: 56
• Category: Article
• ISSN: 0379-0738
• DOI: 10.1016/0379-0738(92)90173-t

✦ Synopsis

A fatality due to the ingestion of bupropion and ethanol is presented. Bupropion and its metabolites were extracted from several tissues and identified using gas chromatography with nitrogenphosphorus and mass spectrometry detection. The concentrations of bupropion, hydroxybupropion and the erythroamino and threoamino alcohol metabolites in heart blood were 4.2, 5.0, 0.6 and 4.6 mg/l, respectively. The heart blood ethanol concentration was 0.27 g/dl. In addition, bupropion was distributed as follows: subclavian blood, 6.2 mg/l; bile, 1.4 mg/l; kidney, 2.4 mg/l; liver, 1.0 mg/kg; stomach contents, 16 mg and urine, 37 mg/l.