Buprenorphine is a potent κ-opioid receptor antagonist in pigeons and mice
✍ Scribed by J.David Leander
- Book ID
- 115881749
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 451 KB
- Volume
- 151
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
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We utilized the [ 35 S]-GTP-␥-S functional binding assay to determine the selectivity of opioid receptor agonists in guinea pig caudate membranes. The study focused on two opioid agonists used for treating opioid-dependent patients: methadone and buprenorphine. Selective antagonists were used to gen
## Abstract 2‐(3,4‐Dichlorophenyl)‐N‐methyl‐N‐[(1S)‐1‐(3‐isothiocyanatophenyl)‐2‐(1‐pyrrolidinyl)ethyl]acetamide (1, DIPPA) has been previously reported to be an opioid receptor affinity label that produces selective and long‐lasting κ opioid receptor antagonism in mice, High specific activity [^3^