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BuMgNiPr2: A New Base for Stoichiometric, Position-Selective Deprotonation of Cyclopropane Carboxamides and Other Weak CH Acids

โœ Scribed by Mao-Xi Zhang; Philip E. Eaton


Book ID
101373801
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
83 KB
Volume
41
Category
Article
ISSN
0044-8249

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BuMgNiPr2: A New Base for Stoichiometric
โœ Mao-Xi Zhang; Philip E. Eaton ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 83 KB

Organolithium (RLi) and -magnesium (R 2 Mg) compounds are kinetically poor bases for proton removal from weak carbon acids. If an amine like N,N,N',N'-tetramethylethylendiamine (TMEDA) is added, the barrier is sometimes lowered, but the nucleophility of the organometallic compound remains a problem.