Bulky Chiral Carbene Ligands and Their Application in the Palladium-Catalyzed Asymmetric Intramolecular α-Arylation of Amides
✍ Scribed by E. Peter Kündig; Thomas M. Seidel; Yi-xia Jia; Gérald Bernardinelli
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 360 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0044-8249
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## Abstract New Enders/Herrmann‐type chiral N‐heterocyclic carbene (NHC) ligands have been developed and applied in asymmetric palladium‐catalyzed intramolecular α‐arylations of amides. The best ligands feature the bulky __tert__‐butyl group and __ortho__‐substituted aryl groups at the stereogenic