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Building blocks for the synthesis of post-translationally modified glycated peptides and proteins

✍ Scribed by Stefano Carganico; Paolo Rovero; Jose A. Halperin; Anna Maria Papini; Michael Chorev

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 140 KB
Volume: 15
Category: Article
ISSN: 1075-2617
DOI: 10.1002/psc.1105

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✦ Synopsis

Abstract

Growing interest in synthetic peptides carrying post‐traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of N^α^‐Fmoc‐Lys‐OH derivatives containing N^ε^‐1‐deoxyfructopyranosyl moiety. Copyright © 2008 European Peptide Society and John Wiley & Sons, Ltd.

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