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Buffering in Models of Integrated Biochemical Systems

✍ Scribed by Eberhard O. Voit; António E.N. Ferreira

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
211 KB
Volume
191
Category
Article
ISSN
0022-5193

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✦ Synopsis

Buffers are a standard tool in biochemistry, yet they have not been used explicitly in models of biochemical systems. We propose simple mathematical modules that provide buffering action against undesired fluctuations in marginal system variables. The results demonstrate that the inclusion of these ''buffer boxes'' is effective. Buffer boxes can be designed so that they do not alter steady-state values of the system. However, depending on the form of the buffer, formerly unstable systems can be stabilized. Buffer boxes do not unduly increase computational cost.

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✍ Michael L. Mavrovouniotis; George Stephanopoulos; Gregory Stephanopoulos 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 992 KB

Aiming to satisfy the need for the formalization of semiquantitative reasoning in the analysis of biochemical systems, the O[M] formalism for reasoning with orders of magnitude and approximate relations has been developed. It is based on seven primitive relations among quantities and compound relati