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Buffer catalysis and hydrogen-deuterium exchange of heteroaromatie carbon acids

✍ Scribed by John A. Zoltewicz; Craig L. Smith; Glenn M. Kauffman

Book ID
112122413
Publisher
Journal of Heterocyclic Chemistry
Year
1971
Tongue
English
Weight
87 KB
Volume
8
Category
Article
ISSN
0022-152X

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## Abstract Multi‐deuterium incorporations into drugs, such as theophylline, caffeine, valpromide, phenytoin, and trimethoprim, were post‐synthetically achieved by Pd/C‐, Pt/C‐, or/and Rh/C‐catalyzed hydrogen–deuterium exchange reactions under neutral conditions using deuterium oxide as the deuteri