Buffalo (Bubalus bubalis) epiphyseal proteins give protection from arsenic and fluoride-induced adverse changes in acetylcholinesterase activity in rats

✍ Scribed by Vijay K. Bharti; R. S. Srivastava; Ajay K. Anand; K. Kusum

• Book ID: 102298622
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 79 KB
• Volume: 26
• Category: Article
• ISSN: 1095-6670
• DOI: 10.1002/jbt.20407

✦ Synopsis

Abstract

The objective of this study was to determine the effect of fluoride (F) and arsenic (As) on the activity of acetylcholinesterase (AChE), a critically important nervous system enzyme, and to test the protective role of buffalo epiphyseal (pineal) proteins (BEP) in rats. Arsenic (20 mg/kg BW, intraperitoneally) and F (150 ppm, perorally) were exposed, and BEP was administered intraperitoneally (100 μ g/kg BW) along with F and As to rats for 7 days. As and F exposure significantly (p < 0.05) increased their levels in plasma and decreased the activity of AChE in plasma, RBCs, heart, and brain of rats. Interestingly, As‐ and F‐induced inhibition of AChE activities increased As and F levels in plasma, and organs were significantly (p < 0.05) counteracted by BEP administration. These findings indicate the protective role of buffalo (Bubalus bubalis) epiphyseal proteins on F‐ and As‐induced adverse changes in AChE activity as a candidate biomarker for neurotoxicity in female rats. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 26:10–15 2012; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20407